東京大学大学院薬学系研究科薬品作用学教室

2021

Watanabe, Y., Okada, M., Ikegaya, Y. Towards threshold invariance in defining hippocampal ripples. J. Neural Eng., in press.

Hoshi, Y., Shibasaki, K., Gailly, P., Ikegaya, Y., Koyama, R. Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment. Sci. Adv., in press.

Ogaki, A., Ikegaya, Y., Koyama, R. Extracellular vesicles taken up by astrocytes. Int. J. Mol. Sci., 22:10553, 2021.

Andoh, M., Koyama, R. Comparative review of microglia and monocytes in CNS phagocytosis. Cells, in press.

Nomura, H., Ikegaya, Y. Histamine: a key neuromodulator of memory consolidation and retrieval. Curr. Top. Behav. Neurosci., in press.

Andoh, M., Koyama, R. Microglia regulate synaptic development and plasticity. Dev. Neurobiol., in press.

Araki, T., Ikegaya, Y., Koyama, R. The effects of microglia- and astrocyte-derived factors on neurogenesis in health and disease. Eur. J. Neurosci., 54:5880-5901. 2021.

Konno, D., Nishimoto, S., Suzuki, T., Ikegaya, Y., Matsumoto, N. Multiple states in ongoing neural activity in the rat visual cortex. PLOS ONE, 16:e0256791, 2021.

Hirata, S., Betsuyaku, T., Fujita, K., Nakano, T., Ikegaya, Y. Phylogeny and ontogeny of mental time. Neurosci. Res., 170:13-17, 2021.

Ogasawara, J., Ikenoue, S., Yamamoto, H., Sato, M., Kasuga, Y., Mitsukura, Y., Ikegaya, Y., Yasui, M., Tanaka, M., Ochiai, D. Deep neural network-based classification of cardiotocograms outperformed conventional algorithms. Sci. Rep., 11:13367, 2021.

Kinoshita, S., Koyama, R. Pro- and anti-epileptic roles of microglia. Neural Regen. Res., 16:1369-1371, 2021.

Sato, Y., Mizuno, H., Matsumoto, N., Ikegaya, Y. Subthreshold membrane potential dynamics of posterior parietal cortical neurons coupled with hippocampal ripples. Physiol. Int., 108:54–65, 2021.

Andoh, M., Koyama, R. Assessing microglial dynamics by live imaging. Front. Immunol., 12:617564, 2021.

Gao, M., Noguchi, A., Ikegaya, Y. The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons. J. Physiol., 599:3151-3167, 2021.

Okonogi, T., Sasaki, T. Theta-range oscillations in stress-induced mental disorders as an oscillotherapeutic target. Front. Behav. Neurosci., 15:698753, 2021.

Nishimura, Y., Ikegaya, Y., Sasaki, T. Concurrent recordings of hippocampal neuronal spikes and prefrontal synaptic inputs from an awake rat. STAR Protoc., 2:100572, 2021.

Yoshimoto, A., Yamashiro, K., Ikegaya, Y., Matsumoto, N. Acute ramelteon treatment maintains the cardiac rhythms of rats during non-REM sleep. Biol. Pharm. Bull., 44:789-797, 2021.

Morikawa, S., Katori, K., Takeuchi, H., Ikegaya, Y. Brain-wide mapping of presynaptic inputs to basolateral amygdala neurons. J. Comp. Neurol., 529:3062-3075, 2021.

Kono, R, Ikegaya, Y., Koyama, R. Phagocytic glial cells in brain homeostasis. Cells, 10:1348, 2021.

Liu, J., Kashima, T., Morikawa, S., Noguchi, A., Ikegaya, Y., Matsumoto, N. Molecular characterization of superficial layers of the presubiculum during development. Front. Neuroanat., 15:662724, 2021.

Iwasaki, S., Sasaki., T., Ikegaya, Y. Hippocampal beta oscillations predict mouse object-location associative memory performance. Hippocampus, 31:503-511, 2021.

Okada, M., Kono, R., Sato, Y., Kobayashi, C., Koyama, R., Ikegaya, Y. Highly active neurons emerging in vitro. J. Neurophysiol., 125:1322-1329, 2021.

Yamashiro, K., Liu, J., Matsumoto, N., Ikegaya, Y. Deep learning-based classification of GAD67-positive neurons without the immunosignal. Front. Neuroanat., 15:643067, 2021.

Noguchi, A., Ikegaya, Y., Matsumoto, N. In vivo whole-cell patch-clamp methods: recent technical progress and future perspectives. Sensors, 21:1448, 2021.

Nishimura, Y., Ikegaya, Y., Sasaki, T. Prefrontal synaptic activation during hippocampal memory reactivation. Cell Rep., 34:108885, 2021.

Chang, D. H. F., Troje, N. F., Ikegaya, Y., Fujita, I., Ban, H. Spatiotemporal dynamics of responses to biological motion in the human brain. Cortex, 136:124-139, 2021.

Onodera, J., Nagata, H., Nakashima, A., Ikegaya, Y., Koyama, R. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia, 69:890-904, 2021.

Shikano, Y., Ikegaya, Y., Sasaki, T. Minute-encoding neurons in hippocampal-striatal circuits. Curr. Biol., 31:1–12, 2021.

Okamoto, K., Ebina, T., Fujii, N., Konishi, K., Sato, Y., Kashima, T., Nakano, R., Hioki, H., Takeuchi, H., Yumoto, J., Matsuzaki, M., Ikegaya, Y. Tb³⁺-doped fluorescent glass for biology. Sci. Adv., 7:eabd2529, 2021.

Zhou, Z., Okamoto, K., Onodera, J., Hiragi, T., Andoh, M., Ikawa, M., Tanaka, K. F., Ikegaya, Y., Koyama R. Astrocytic cAMP modulates memory via synaptic plasticity. Proc. Natl. Acad. Sci. U. S. A., 118:e2016584118, 2021.

Iwasaki, S., Ikegaya, Y. Contextual fear memory retrieval is vulnerable to hippocampal noise. Cereb. Cortex, 31:785–794, 2021.

Igata, H., Ikegaya, Y., Sasaki, T. Prioritized experience replays on a hippocampal predictive map for learning. Proc. Natl. Acad. Sci. U. S. A., 118:e2011266118, 2021.

Okonogi, T., Sasaki, T. Optogenetic manipulation of the vagus nerve (book chapter). Optogenetics, 459-470, 2021.

Yoshimoto, A., Yamashiro, K., Suzuki, T., Ikegaya, Y., Matsumoto, N. Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep. J. Pharmacol. Sci., 145:97-104, 2021.

Ogasawara, J., Matsumoto, N., Yokokawa, T., Yasui, M., Ikegaya, Y. Machine learning-based individual identification of laboratory mice. Asian J. Anim. Sci., 15:27-34, 2021.

竹内春樹、嗅覚回路形成の分子基盤、日本味と匂学会誌、28:11-15, 2021.

安藤めぐみ、小山隆太、ミクログリアによる脳の恒常性維持とその破綻としての神経疾患、生化学、93:248-251, 2021.

河野玲奈、池谷裕二、小山隆太、脳内貪食細胞の謎に迫る、和光純薬時報、89:8-9, 2021.

2020

Nakashima, A., Ihara, N., Ikegaya, Y., Takeuchi, H. Cell type-specific patterned neural activity instructs neural map formation in the mouse olfactory system. Neurosci. Sci., in press.
Ogaki, A., Araki, T., Ishikawa, M., Ikegaya, Y., Koyama, R. A live imaging-friendly slice culture method using collagen membranes. Neuropsychopharmacol. Rep., 40:307-313, 2020.
Numasawa, K., Hanaoka, K., Ikeno, T., Echizen, H., Ishikawa, T., Morimoto, M., Komatsu, T., Ueno, T., Ikegaya, Y., Nagano, T., Urano, Y. A cytosolically localized far-red to near-infrared rhodamine-based fluorescentprobe for calcium ions. Analyst, 145:7736-7740, 2020.
Ishikawa, T., Kobayashi, C., Takahashi, N., Ikegaya, Y. Functional multiple-spine calcium imaging from brain slices. STAR Protoc., 1:100121, 2020.
Yesbolatova, A., Saito, Y., Kitamoto, N., Makino-Itou, H., Ajima, R., Nakano, R., Nakaoka, H., Fukui, K., Gamo, K., Tominari, Y., Takeuchi, H., Saga, Y., Hayashi, K., Kanemaki, M.T. The auxin-inducible degron technology gives sharp degradation control in 2 yeast, mammalian cells, and mice. Nat. Commun., 11:5701, 2020.
Miyake, K., Yagi, S., Shikano, Y., Aoki, Y., Ikegaya, Y., Sasaki, T. Acute effects of ethanol on hippocampal spatial representation and offline reactivation. Front. Cell. Neurosci., 14:571175, 2020.
Hoang, H., Sato, M.A., Shinomoto, S.,Tsutsumi, S., Hashizume, M., Ishikawa, T., Kano, M., Ikegaya, Y., Kitamura, K., Kawato, M., Toyama, K. Improved hyperacuity estimation of spike timing from calcium imaging. Sci. Rep., 10:17844.2020.
Yagishita , H., Nishimura, Y., Noguchi, A., Shikano, Y., Ikegaya, Y., Sasaki, T. Urethane anesthesia suppresses hippocampal subthreshold activity and neuronal synchronization. Brain Res., 1749:147137, 2020.
Yamashiro, K., Aoki, M., Matsumoto, N., Ikegaya, Y. Polyherbal formulation enhancing cerebral slow waves in sleeping rats. Biol. Pharm. Bull., 43:1356–1360, 2020.
Andoh, M., Ikegaya, Y., Koyama, R. Microglia modulate the structure and function of the hippocampus after early-life seizures. J. Pharmacol. Sci., 144:212-217, 2020.
Andoh, M., Ikegaya, Y., Koyama, R. Microglia in animal models of autism spectrum disorders. Prog. Mol. Biol. Transl. Sci., 173:239-273, 2020.
Orita, K., Sawada, K., Matsumoto, N., Ikegaya, Y. Machine-learning-based quality control of contractility of cultured human-induced pluripotent stem-cell-derived cardiomyocytes. Biochem. Biophy. Res. Commun., 526:751-755, 2020.
Andoh, M., Koyama, R. Exercise, microglia, and beyond – workout to communicate with microglia. Neural Regen. Res., 15:2029-2030, 2020.
Araki, T., Ikegaya, Y., Koyama, R. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacol. Rep., 40:85-91, 2020.
Nishimura, Y., Fukuda, Y., Okonogi, T, Karasuyama, H., Osakabe, N., Ikegaya, Y., Yoshikawa, S., Sasaki, T., Adachi, T. Dual real-time in vivo monitoring system of the brain-gut axis. Biochem. Biophy. Res. Commun., 524:340-345, 2020.
Miyawaki, T., Morikawa, S., Susaki, E. A., Nakashima, A., Takeuchi, H., Yamaguchi, S., Ueda, H. R., Ikegaya, Y. Visualization and molecular characterization of whole-brain vascular networks with capillary resolution. Nat. Commun., 11:1104, 2020.
Ishikawa, T., Ikegaya, Y. Locally sequential synaptic reactivation during hippocampal ripples. Sci. Adv., 6:eaay1492, 2020.
Ogaki, A., Ikegaya, Y., Koyama, R. Vascular abnormalities and the role of vascular endothelial growth factor (VEGF) in the epileptic brain. Front. Pharmacol., Front. Pharmacol., 11:20, 2020.
Motegi, Y., Sato, M., Horiguchi, K., Ohkura, M., Gengyo-Ando, K., Ikegaya, Y., Fusamae, Y., Hongo, Y., Suzuki, M., Ogawa, K., Takaki, M., Nakai, J. Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice. Neurosci. Res., 151:53-60, 2020.
大柿安里、池谷裕二、小山隆太、てんかん新規治療標的としての神経血管ユニット、BIO Clinica、35:89-92, 2020.
池谷裕二、河村満、誰もが「でこぼこ」の脳を持っている、BRAIN and NERVE、72:187-192, 2020.
池谷裕二、ASCEPT-PAGANZ合同年会2019に参加して、日本薬理学雑誌、155:120, 2020.
大柿安里、池谷裕二、小山隆太、てんかん脳における血管異常、Medical Science Digest、46:104-107, 2020.
周至文、池谷裕二、小山隆太、光活性化アデニル酸シクラーゼ（PAC）の利用によるアストロサイト機能の解明、細胞、2:33-36, 2020.

2019

Kono, R., Kim, G., Nagata, H., Ikegaya, Y., Koyama, R. Induced neuronal activity does not attenuate amyloid beta-induced synapticloss in vitro. Neuropsychopharmacol. Rep., 39:306-311, 2019.
Kuga, N., Nakayama, R., Shikano, Y., Nishimura, Y., Okonogi, T., Ikegaya, Y., Sasaki, T. Sniffing behaviour-related changes in cardiac and cortical activity in rats. J. Physiol., 597:5295-5306, 2019.
Kojima, H., Rosendale, M., Sukiyama, Y., Hayashi, M., Horiguchi, Y., Yoshihara,T., Ikegaya, Y., Saneyoshi,T., Hayashi, Y. The role of CaMKII-Tiam1 complex on learning and memory. Neurobiol. Learn. Mem., 166:107070, 2019.
Andoh, M., Ikegaya, Y., Koyama, R. Synsaptic pruning by microglia in epilepsy. J. Clin. Med., 8:2170, 2019.
Kobayashi, R., Maruoka, J., Norimoto, H., Ikegaya, Y., Kume, K., Ohsawa, M. Involvement of L-Lactate in Hippocampal Dysfunction of Type I Diabetes. J. Pharmacol. Sci. ,141:79-82, 2019.
Konno, D., Nakayama, R., Tsunoda, M., Funatsu, T., Ikegaya, Y., Sasaki, T. Collection of biochemical samples with brain-wide electrophysiological recordings from a freely moving rodent. J. Pharmacol. Sci., 140:313-316, 2019.
Orita, K., Sawada, K., Koyama, R., Ikegaya, Y. Deep learning-based quality control of cultured human-induced pluripotent stem cell-derived cardiomyocytes.J. Pharmacol. Sci., 140:313-316, 2019.
Ikegaya, Y., Matsumoto, N. Spikes in the sleeping brain. Science,366:306-307, 2019.
Andoh, M., Ikegaya, Y., Koyama, R., Microglia as possible therapeutic targets for autism spectrum disorders. Prog. Mol. Biol. Transl. Sci., 167:223-245, 2019.
Noguchi, A., Sakaguchi, T., Sato, M., Aikawa, H., Matsumoto, N., Ikegaya, Y. Whisker electromyograms signify awake and anesthetized states in mice. Neurosci. Res., 148: 61-65, 2019.
Nakashima, A., Ihara, N., Shigeta, M., Kiyonari, H., Ikegaya, Y., Takeuchi, H. Structured spike series specify gene expression patterns for olfactory circuit formation. Science, 365:eaaw5030, 2019. recommended in F1000 prime.
Nakano, R., Ihara, N., Morikawa S., Kanemaki, M., Ikegaya, Y., Takeuchi,H. Auxin-mediated rapid degradation of target proteins in hippocampal neurons. Neuroreport, 30:908-913, 2019.
Nakayama, R., Ikegaya, Y., Sasaki, T. Cortical-wide functional correlations are associated with stress-induced cardiac dysfunctions in individual rats. Sci. Rep., 9:10581, 2019.
Nomura, H., Mizuta, H., Norimoto, H., Masuda, F., Miura, Y., Kubo, A.,Kojima, H., Ashizuka, A., Matsukawa, N., Baraki, Z., Hitora-Imamura, N., Nakayama, D., Ishikawa, T., Okada, M., Orita, K., Saito, R., Yamauchi,N., Sano, Y., Kusuhara, H., Minami, M., Takahashi, H., Ikegaya, Y. Central histamine boosts perirhinal cortex activity and restores forgotten object memories. Biol. Psychiat., 86: 230-239, 2019.
Sasaki, T. A physiolomics approach to reveal systemic organ dynamics in a rodent. Biol. Pharm. Bull., 42:1059-1063, 2019.
Andoh, M., Shibata, K., Okamoto, K., Onodera, J., Morishita, K., Miura, Y., Ikegaya, Y., Koyama, R. Exercise reverses behavioral and synaptic abnormalities after maternal inflammation. Cell Rep., 27:2817-2825, 2019.
Abe, R., Okada, S., Nakayama, R., Ikegaya, Y, Sasaki, T. Social defeat stress causes selective attenuation of neuronal activity in the ventromedial prefrontal cortex. Sci. Rep., 9:9447, 2019. recommended in F1000 prime.
Kashima, T., Noguchi, A., Ikegaya, Y., Matsumoto, N. Heterogeneous expression patterns of fibronectin in the mouse subiculum. J. Chem. Neuroanat., 98:131-138, 2019.
Sasaki, T., Suzuki, I., Yokoi, R., Sato, K., Ikegaya, Y. Synchronous spike patterns in differently mixed cultures of human iPSC-derived glutamatergic and GABAergic neurons. Biochem. Biophy. Res. Commun., 513:300-305, 2019.
Aoki, Y., Igata, H., Ikegaya, Y., Sasaki, T. Integration of goal-directed signals onto spatial maps of hippocampal place cells. Cell Rep., 27:1516-1527, 2019.
Nomura, H., Teshirogi, C., Nakayama, D., Minami, M., Ikegaya, Y. Prior observation of fear learning enhances subsequent self-experienced fear learning with an overlapping neuronal ensemble in the dorsal hippocampus. Mol. Brain, 12:21, 2019.
Gao, M., Orita, K., Ikegaya, Y. Maternal immune activation in pregnant mice produces offspring with altered hippocampal ripples. Biol. Pharm. Bull., 42:666-670, 2019.
Kasahara, Y., Igata, H., Sasaki, T., Ikegaya, Y., Koyama, R. The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice. eNeuro, e0429-18, 2019.
Shikano, Y., Nishimura, Y., Okonogi, T., Ikegaya, Y., Sasaki, T. Vagus nerve spiking activity associated with locomotion and cortical arousal states in a freely moving rat. Eur. J. Neurosci., 49:1298-1312, 2019.
Kobayashi, C., Okamoto, K., Mochizuki, Y., Urakubo, H., Funayama, F., Ishikawa, T., Kashima, T., Szymanska, A. F., Ouchi, A., Ishii, S., Ikegaya, Y. GABAergic inhibition reduces the impact of synaptic excitation on somatic excitation. Neurosci. Res., 146:22-35, 2019.
Sasaki, T., Non-structured spike sequences of hippocampal neuronal ensembles in awake animals. Neurosci. Res., 142:1-6, 2019.
Okamoto, K., Ikegaya, Y. Recurrent connections between CA2 pyramidal cells. Hippocampus, 29:305-312, 2019.
Zhou, Z., Ikegaya, Y., Koyama, R., The astrocytic cAMP pathway in health and disease. Int. J. Mol., 20:779, 2019.
Sato, Y., Miyawaki, T., Ouchi, A., Noguchi, A., Yamaguchi, S., Ikegaya, Y. Quick visualization of neurons in brain tissues using an optical clearing technique. Anat. Sci. Int., 94:199-208, 2019.
Kayama, T., Okamoto, K., Gao, M., Ikegaya, Y., Sasaki, T. Immature electrophysiological properties of human-induced pluripotent stem cell-derived neurons transplanted into the mouse cortex for seven weeks. Neuroreport, 30:169-173, 2019.
Sanders, H., Ji, D., Sasaki, T., Leutgeb, J. K., Wilson, M. A., Lisman, J. E. Temporal coding and rate remapping: Representation of non-spatial information in the hippocampus. Hippocampus, 29:111-127, 2019.
星雄高、小山隆太、脳疾患におけるTRPV4の関与、医学のあゆみ、270:930-933, 2019.
伊原尚樹、中嶋藍、池谷裕二、竹内春樹、神経活動パターン依存的な嗅覚神経回路の形成機構、Aroma Research、80:57-61, 2019.
中野利沙子、伊原尚樹、池谷裕二、竹内春樹、自発活動パターンに依存した嗅覚神経回路の精緻化機構、日本味と匂い学会誌、26:53-57, 2019.
安藤めぐみ、池谷裕二、小山隆太、自閉症におけるミクログリア依存的シンプス除去の不全とその回復、実験医学、37:110-117, 2019.
小林千晃、抑制性シナプス入力による興奮性シナプス入力の無効化、神経科学ニュース、219:25-28, 2019.
大内彩子、佐々木拓哉、池谷裕二、海馬神経同期発火の生理的意義に関する最近の知見、月刊「細胞」、51:266-269, 2019.
中山亮太、池谷裕二、佐々木拓哉、末梢臓器動態に基づく動物の精神状態の評価、日本薬理学雑誌、153: 161-164, 2019.
池谷裕二、奨励賞受賞佐々木拓哉氏の業績、ファルマシア、55:579, 2019.

2018

Iwasaki, S., Ikegaya, Y. In vivo one-photon confocal calcium imaging of neuronal activity from the mouse neocortex. J. Integr. Neurosci., 17:671-678, 2018.
Katori, K., Manabe, H., Nakashima, A., Eerdunfu, Sasaki, T., Ikegaya, Y., Takeuchi H. Sharp wave-associated activity patterns of cortical neurons in the mouse piriform cortex. Eur. J. Neurosci., 48:3246-3254, 2018.
Shikano, Y., Sasaki, T., Ikegaya, Y., Monitoring brain neuronal activity with manipulation of cardiac events in a freely moving rat. Neurosci. Res., 136:56-62, 2018.
Sakamoto, S., Takeuchi, H., Ihara, N., Bao ligao, B., Suzukawa, K. Possible requirement of executive functions for high performance in soccer. PLOS ONE, 13:e0201871, 2018.
Sakaguchi, T., Iwasaki, S., Okada, M., Okamoto, K., Ikegaya, Y. Ethanol facilitates socially-evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons. Nat. Commun., 9:3526, 2018.
Sato, M., Matsumoto, N., Noguchi, A., Okonogi, T., Sasaki, T., Ikegaya, Y. Simultaneous monitoring of mouse respiratory and cardiac rates through a single precordial electrode. J. Pharmacol. Sci., 137:177-186, 2018.
Desantis, A., Haggard, P., Ikegaya, Y., Hagura, N. Specificity of action selection modulates the perceived temporal order of action and sensory events. Exp. Brain Res., 236:2157-2164, 2018.
Hoshi, Y., Okabe, K., Shibasaki, K., Funatsu, T., Matsuki, N., Ikegaya, Y., Koyama, R. Ischemic brain injury leads to brain edema via hyperthermia-induced TRPV4 activation. J. Neurosci., 38:5700-5709, 2018.
Yagi, S., Igata, H., Shikano, Y., Aoki, Y., Sasaki, T., Ikegaya, Y. Time-varying synchronous cell ensembles during consummatory periods correlate with variable numbers of place cell spikes. Hippocampus, 28:471-483, 2018.
Okamoto, K., Hitora-Imamura, N., Hioki, H., Ikegaya, Y. GABAergic malfunction in the anterior cingulate cortex underlying maternal immune activation-induced social deficits. J. Neuroimmunol., 321:92-96, 2018.
Koyama, R., Ikegaya, Y. The molecular and cellular mechanisms of axon guidance in mossy fiber sprouting. Front. Neurol., 9:382, 2018.
Kasahara Y., Ikegaya, Y., Koyama, R. Neonatal seizure models to study epileptogenesis. Front. Pharmacol., 9:385, 2018.
Yawata, Y., Makino, K., Ikegaya, Y. Answering hastily retards learning. PLOS ONE, 13:e0195404, 2018.
Chang, D.H.F., Ban, H., Ikegaya, Y., Fujita, I., Troje, N.F. Cortical and subcortical responses to biological motion. Neuroimage, 174:87-96, 2018.
Okonogi, T., Nakayama, R., Sasaki, T., Ikegaya, Y. Characterization of peripheral activity states and cortical local field potentials of mice in an elevated plus maze test. Front. Behav. Neurosci., 12:62, 2018.
Shikano, Y., Sasaki, T., Ikegaya, Y., Simultaneous recordings of cortical local field potentials, electrocardiogram, electromyogram, and breathing rhythm from a freely moving rat. J. Vis. Exp., 134:e56980, 2018.
Norimoto, H., Makino, K., Gao, M., Shikano, Y., Okamoto, K., Ishikawa, T., Sasaki, T., Hioki, H., Fujisawa, S., Ikegaya, Y. Hippocampal ripples down-regulate synapses. Science, 359:1524-1527, 2018.
Hiragi, T., Ikegaya, Y., Koyama, R. Microglia in Epilepsy. Cells, 7:26, 2018.
Sasaki, T., Piatti, V. C., Hwaun, E., Ahmadi. S., lisman, J. E., Leutgeb, S., Leutgeb, J. Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons. Nat. Neurosci., 21:258-269, 2018.
Kayama, T., Suzuki, I., Odawara, A., Sasaki, T., Ikegaya, Y. Temporally coordinated spiking activity of human induced pluripotent stem cell-derived neurons co-cultured with astrocytes. Biochem. Biophys. Res. Commun., 495:1028-1033, 2018.
佐々木拓哉、神経回路とシナプス動態を繋ぐ研究の一例、細胞、50:151, 2018.
牧野健一、ひらめきに付随する「アハ体験」とドパミンの神経相関、ファルマシア、54:1166, 2018.
大柿安里、池谷裕二、小山隆太、ミクログリアは免疫記憶するか？、実験医学、36:2222-2223, 2018.
牧野健一、池谷裕二、記憶を促通する学習パラダイムとその原理、BRAIN and NERVE、70:821-828, 2018.
鹿野悠、佐々木拓哉、池谷裕二、海馬神経細胞の時間表象、BRAIN and NERVE, 69:1233-1239, 2018.
高夢璇、佐藤元重、池谷裕二、人工知能を用いた薬物副作用の予測、薬学雑誌、138:809-813, 2018.
佐藤薫、池谷裕二、神経系非臨床試験のヒト予測性向上への挑戦 ―― 人工知能（AI）及びヒト神経細胞マテリアルの可能性、薬学雑誌、138:807, 2018.
折田健、渡邉裕亮、池谷裕二、AIを用いた治療薬の有効性、副反応、薬物相互作用の評価、腎臓、40:19-22, 2018.

2017

Okada, S., Igata, H., Sasaki, T., Ikegaya, Y. Spatial representation of hippocampal place cells in a T-maze with an aversive stimulation. Front. Neural Circuits, 11:101, 2017.
Hiragi, T., Andoh, M., Araki, T., Shirakawa, T., Ono, T., Koyama, R., Ikegaya, Y. Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures. Front. Cell. Neurosci., 11:143, 2017.
Minamisawa, G., Funayama, K., Matsumoto, N., Matsuki, N., Ikegaya, Y. Flashing lights induce prolonged distortions in visual cortical responses and visual perception. eNeuro, 4, 2017.
Noguchi, A., Matsumoto, N., Morikawa, S. Tamura, H., Ikegaya, Y. Juvenile hippocampal CA2 region expresses aggrecan. Front. Neuroanat., 11:41, 2017.
Watanabe, Y., Ikegaya, Y. Caffeine increases hippocampal sharp waves in vitro. Biol. Pharm. Bull., 40:1111-1115, 2017.
Ouchi, A., Matsumoto, N., Ikegaya, Y. Activation of hilar mossy cells and dentate granule cells during sharp wave/ripples. Curr. Res. Neurosci., 7:1-8, 2017.
Sasaki, T., Nishimura, Y., Ikegaya, Y. Simultaneous recordings of central and peripheral bioelectrical signals in a freely moving rodent. Biol. Pharm. Bull., 40:711-715, 2017.
Ihara, N., Ikegaya, Y., Takeuchi, H. Quadruple immunostaining of the olfactory bulb for visualizing the molecular identity codes of olfactory sensory axons. J. Vis. Exp., 124, 2017.
Aoki, Y., Nishimura, Y., Hondrich, T., Nakayama, R., Igata, H., Sasaki, T., Ikegaya, Y. Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model. J. Physiol. Sci., 67:507-513, 2017.
Ujita, S., Sasaki, T., Asada, A., Funayama, K., Gao, M., Mikoshiba, K., Matsuki, N., Ikegaya, Y. cAMP-dependent calcium oscillations of astrocytes: an implication for pathology. Cereb. Cortex, 27:1602-1614, 2017.
Hirabayashi, K., Hanaoka, K., Egawa, T., Kobayashi, C., Takahashi, S., Komatsu, T., Ueno, T., Terai, T., Ikegaya, Y., Nagano, T., Urano, Y. Synthesis of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability. Data Brief, 12:351-357, 2017.
Dunfu, E., Ihara, N., ligao, B., Ikegaya, Y., Takeuchi, H. Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons. Neural Dev., 12:2, 2017.
Morikawa, S., Ikegaya, Y., Narita, M., Tamura, H. Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval. Sci. Rep., 7:46024, 2017.
Gao, M., Igata, H., Takeuchi, A., Sato, K., Ikegaya, Y. Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds. J. Pharmacol. Sci., 133:70-78, 2017.
鹿野悠、佐々木拓哉、池谷裕二、海馬神経細胞の時間表象、BRAIN and NERVE、69: 1233-1239, 2017.
笠原由佳、池谷裕二、小山隆太、マウス熱性けいれんモデルの作製、日本薬理学雑誌、150: 240-245, 2017.
八幡洋輔、佐々木拓哉、動物の個性を考慮した行動解析、日本薬理学雑誌、150: 116, 2017.
佐々木拓哉、海馬の場所細胞と病態研究、日本薬理学雑誌、149: 247, 2017.
佐々木拓哉、中枢末梢連関の理解に向けた生体電気信号の網羅的解析、日本薬理学雑誌、149: 167-172, 2017.
岡田桜、青木勇樹、佐々木拓哉、池谷裕二、海馬研究の最前線、BRAIN and NERVE、69:453-460, 2017.
佐村俊和、池谷裕二、佐藤能臣、海馬CA3培養スライスの自発的な神経発火を再現する神経回路の推定、生物物理、57:33-35, 2017.
池谷裕二、脳回路活動の構造解析、ブレインサイエンス・レビュー、43-58, 2017.

2016

Matsumoto, N. Okamoto, K., Takagi, Y., Ikegaya, Y. 3-Hz subthreshold oscillations of CA2 neurons in vivo. Hippocampus, 26:1570-1578, 2016.
Funayama, K., Hagura, N., Ban, H., Ikegaya, Y. Functional organization of flash-induced V1 offline reactivation. J. Neurosci., 36:11727-11738, 2016.
Luo, C., Ikegaya, Y., Koyama, R. Microglia and neurogenesis in the epileptic dentate gyrus. Neurogenesis, 3:e1235525, 2016.
Mikami, Y., Kanemaru, K., Okubo, Y., Nakaune, T., Suzuki, J., Shibata, K., Sugiyama, H., Koyama, R., Murayama, T., Ito, A., Yamazawa, T., Ikegaya, Y., Sakurai, T., Saito, N., Kakizawa, S., Iino, M. Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death. EBioMedicine, 11:253-261, 2016.
Okada, S., Igata, H., Sakaguchi, T., Sasaki, T., Ikegaya, Y. A new device for the simultaneous recording of cerebral, cardiac, and muscular electrical activity in freely moving rodents. J. Pharmacol. Sci., 32:105-108, 2016.
Kasahara, Y., Koyama, R., Ikegaya, Y. Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Neurosci. Res., 111:64-69, 2016.
Makino, K., Funayama, K., Ikegaya, Y. Re-analysis on geometric energy. Anat. Sci. Int., 91:425-426, 2016.
Ando, M., Koyama, R ., Ikegaya, Y. Severity of kainic acid-induced seizures is not aggravated in the maternal immune activation mouse model of gestational poly(I:C) exposure. J. Autism Epilepsy, 1:1003, 2016.
Hirabayashi, K., Hanaoka, K., Egawa, T., Kobayashi, C., Takahashi, S., Komatsu, T., Ueno, T., Terai, T., Ikegaya, Y., Nagano, T., Urano, Y. Development of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability. Cell Calcium, 17:27, 2016.
Luo, C. Koyama, R. Ikegaya, Y. Microglia engulf viable newborn cells in the epileptic dentate gyrus. Glia, 64:1508-1517, 2016.
Ihara, N., Nakashima, A., Hoshina, N., Ikegaya, Y. Takeuchi, H. Differential expression of axon-sorting molecules in mouse olfactory sensory neurons. Eur. J. Neurosci., 44:1998-2003, 2016.
Takeda, A., Nomura, H., Masamitsu, N., Matsuki, N., Ikegaya, Y., Terai, T., Ueno, T., Hanaoka, K., Nagano, T., Urano, Y., Komatsu, T. Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA. Chembiochem, 17:1233-1240, 2016.
Nishimura, R., Abe, R., Sasaki, T., Ikegaya, Y. Homeostatic changes in neuronal network oscillations in response to continuous hypoperfusion in the mouse forebrain. Neurosci. Res., 109:28-34, 2016.
Okada, M. Ishikawa, T. Ikegaya, Y. A computationally efficient filter for reducing shot noise in low S/N data. PLOS One, 11:e0157595, 2016.
Oba, S., Nakae, K., Ikegaya, Y., Aki, S., Yoshimoto, J., Ishii, S. Empirical Bayesian significance measure of neuronal spike response. BMC Neurosci., 17:27, 2016.
Ohki, M., Sugiyama, K., Kawai, F., Tanaka, H., Nihei, Y., Unzai, S., Takebe, M., Matsunaga, S., Adachie, S., Shibayama, N., Zhou, Z., Koyama, R., Ikegaya, Y., Takahashi, T., Tame, J.R.H., Iseki, M., Park, S.Y. Structural basis for photoactivation of a light-regulated adenylate cyclase from the photosynthetic cyanobacterium Oscillatoria acuminatea. Proc. Natl. Acad. Sci. U. S. A., 113:6659-6664, 2016.
Nakayama, R., Sasaki, T., Tanaka, K. F., Ikegaya, Y. Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes. Eur. J. Neurosci., 43:923-932, 2016.
Igata, H., Sasaki, T., Ikegaya, Y. Early failures benefit subsequent task performance. Sci. Rep., 6:21293, 2016.
Nakayama, D., Hashikawa-Yamasaki, Y., Ikegaya, Y., Matsuki, N., Nomura, H. Late Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories. Sci. Rep., 6:21007, 2016.
Tao, K., Ichikawa, J., Matsuki, N., Ikegaya, Y., Koyama, R. Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. Neuroscience, 318:34-44, 2016.
Takahashi, N., Kobayashi, C., Ishikawa, T., Ikegaya, Y. Subcellular imbalances in synaptic activity. Cell Rep., 14:1348-1354, 2016.
Sajo, M., Sugiyama, H., Yamamoto, H., Tanii, T., Matsuki , N., Ikegaya, Y., Koyama, R. Neuraminidase-dependent degradation of polysialic acid is required for the lamination of newly generated neurons. PLOS One, 11:e0146398, 2016.
Zhou, Z., Tanaka, K. F., Matsunaga, S., Iseki, M., Watanabe, M., Matsuki , N., Ikegaya, Y., Koyama, R. Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Sci. Rep., 5:19679, 2016.
Makino, K., Funayama, K., Ikegaya, Y. Spatial clusters of constitutively active neurons in mouse visual cortex. Anat. Sci. Int., 91:188?195, 2016.
Koyama, R. Dentate circuitry as a model to study epileptogenesis. Biol. Pharm. Bull. 39:891-896, 2016.
安藤めぐみ、池谷裕二、小山隆太、自閉スペクトラム症とてんかん、日本薬理学雑誌、148:121-122, 2016.

2015

Szymanska, A. F., Kobayashi, C., Norimoto, H., Ishikawa, T., Ikegaya, Y., Nenadic, Z. Accurate detection of low signal-to-noise ratio neuronal calcium transient waves using a matched filter. J. Neurosci. Meth., 259:1?12, 2015.
Hitora-Imamura, N., Miura, Y., Teshirogi, C., Ikegaya, Y., Matsuki, N., Nomura, H. Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits. elife, 4:e08274, 2015.
Nomura, H., Hara, K., Abe, R., Hitora-Imamura, N., Nakayama, R., Sasaki, T., Matsuki, N., Ikegaya, Y. Memory formation and retrieval of neuronal silencing in the auditory cortex. Proc. Natl. Acad. Sci. U. S. A., 112:9740-9744, 2015.
Funayama, K., Minamisawa, G., Matsumoto, N., Ban, H., Chan, A. W., Matsuki, N., Murphy, T. H., Ikegaya, Y. Neocortical rebound depolarization enhances visual perception. PLOS Biol., 13:e1002231, 2015.
Asada, A., Ujita, S., Nakayama, R., Oba, S., Ishii, S., Matsuki, N., Ikegaya, Y. Subtle modulation of ongoing calcium dynamics in astrocytic microdomains by sensory inputs. Physiol. Rep., 3:e12454, 2015.
Hongo, Y., Ogawa, K., Takahara, Y., Takasu, K., Royer, S., Hasegawa, M., Sakaguchi, G., Ikegaya, Y. Topological organization of CA3-to-CA1 excitation. Eur. J. Neurosci., 42:2135-2143, 2015.
Hongo, Y., Takasu, K., Ikegaya, Y., Hasegawa, M., Sakaguchi, G., Ogawa, K. Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model: a functional multineuron calcium imaging study. Eur. J. Neurosci., 42:1818-1829, 2015.
Kitanishi, T., Ujita, S., Fallahnezhad, M., Kitanishi, N., Ikegaya, Y., Tashiro, A. Novelty-induced phase-locked firing to slow gamma oscillations in the hippocampus: requirement of synaptic plasticity. Neuron, 86:1265-1276, 2015.
Ishikawa, T., Okamoto, K., Ikegaya, Y. Homeostatic hippocampal activity against reduced glutamatergic neurotransmission. Int. J. Pharmacol., 11:318-326, 2015.
Shimazaki, H., Sadegh, K., Ishikawa, T., Ikegaya, Y., Toyoizum, T. Simultaneous silence organizes structured higher-order interactions in neural populations. Sci. Rep., 5:9821, 2015.
Norimoto, H., Ikegaya, Y. Visual cortical prosthesis with a geomagnetic compass restores spatial navigation in blind rats. Curr. Biol., 21:1091?1095, 2015.
Iwasaki, S., Sakaguchi, T., Ikegaya, Y. Brief fear preexposure facilitates subsequent fear conditioning. Neurosci. Res., 95:66?73, 2015.
Nakayama, D., Iwata, H., Teshirogi, C., Ikegaya, Y., Matsuki, N., Nomura, H. Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. J. Neurosci., 5:819?830, 2015.
Nakayama, D., Baraki, Z., Onoue, K., Ikegaya, Y., Matsuki, N., Nomura, H. Frontal association cortex is engaged in stimulus integration during associative learning. Curr. Bol., 25:117-123, 2015.
Koyama, R., Ikegaya Y., Microglia in the pathogenesis of autism spectrum disorders. Neurosci. Res., 100:1-5, 2015.
Samura, T., Ikegaya, Y., Sato, Y. D. A neural network model of reliably optimized spike transmission. Cogn. Neurodyn., 9:265-77, 2015.
西村侑也、杉山弘樹、池谷裕二、Q&A-神経科学の素朴な疑問、Clin. Neurosci.、 33:1434, 2015.
小島弘人、坂口哲也、池谷裕二、記憶の脳回路痕跡、BRAIN and NERVE、67:599-604, 2015.
高木夕貴、杉山弘樹、池谷裕二、海馬における記憶再生のメカニズム、Clin. Neurosci.、33:225-225, 2015.

2014

Nakae, K., Ikegaya, Y., Ishikawa, T., Oba, S., Urakubo, H., Koyama, M., Ishii, S. A statistical method of identifying interactions in neuron?glia systems based on functional multicell calcium imaging. PLOS Comput. Biol., 10:e1003949, 2014.
Abe, R., Sakaguchi, T., Kitajo, K., Ishikawa, D., Matsumoto, N., Matsuki, N., Ikegaya, Y. Sound-induced modulation of hippocampal theta oscillations. Neuroreport, 25:1368-1374, 2014.
Okamoto, K., Ishikawa, T., Abe, R., Ishikawa, D., Kobayashi, C., Mizunuma, M., Norimoto, H., Matsuki, N., Ikegaya, Y. Ex vivo cultured neuronal networks emit in vivo-like spontaneous activity. J. Physiol. Sci., 64:421-431, 2014.
Miyawaki, T., Norimoto, H., Ishikawa, T., Watanabe, Y., Matsuki, N., Ikegaya, Y. Dopamine receptor activation reorganizes neuronal ensembles during hippocampal sharp waves in vitro. PLOS One, 9:e104438, 2014.
Nonaka, A., Toyoda, T., Miura, Y., Hitora-Imamura, N., Naka, M., Eguchi, M., Yamaguchi, S., Ikegaya, Y., Matsuki, N., Nomura, H. Synaptic plasticity associated with a memory engram in the basolateral amygdala. J. Neurosci., 34:9305?9309, 2014.
Tao, K., Matsuki, N., Koyama, R., AMP-activated protein kinase mediates activity-dependent axon branching by recruiting mitochondria to axon. Dev. Neurobiol., 74:557-573, 2014.
Abe, R., Sakaguchi, T., Matsumoto, N., Matsuki, N., Ikegaya, Y. Sound-induced hyperpolarization of hippocampal neurons. Neuroreport, 25:1013-1017, 2014.
Onoue, K., Nakayama, D., Ikegaya, Y., Matsuki, N., Nomura, H. Fear extinction requires Arc/Arg3.1 expression in the basolateral amygdala. Mol. Brain, 7:30, 2014.
Sasaki, T., Ishikawa, T., Abe, R., Nakayama, R., Asada, A., Matsuki, N., Ikegaya, Y. Astrocyte calcium signaling orchestrates neuronal synchronization in organotypic hippocampal slices. J. Physiol., 592:2771-2783, 2014.
Sasaki, T., Matsuki, N., Ikegaya, Y. Interneuron firing precedes sequential activation of neuronal ensembles in hippocampal slices. Eur. J. Neurosci., 39:2027-2036, 2014.
Ishikawa, D., Matsumoto, N., Sakaguchi, T., Matsuki, N., Ikegaya, Y. Operant conditioning of synaptic and spiking activity patterns in single hippocampal neurons. J. Neurosci., 34:5044-5053, 2014.
Mizunuma, M., Norimoto, H., Tao, K., Egawa, T., Hanaoka, K., Sakaguchi, T., Hioki, H., Kaneko, T., Yamaguchi, S., Nagano, T., Matsuki, N., Ikegaya, Y. Unbalanced excitability underlies offline reactivation of behaviorally activated neurons. Nat. Neurosci., 17:503-505, 2014.
Kobayashi, C., Ohkura, M., Nakai, J., Matsuki, N., Ikegaya, Y., Sasaki, T. Large-scale imaging of subcellular calcium dynamics of cortical neurons with G-CaMP6-actin. Neuroreport, 25:501-506, 2014.

Before 2013 (selected)

Koyama, R., Tao, K., Sasaki, T., Ichikawa, J., Miyamoto, D., Muramatsu, R., Matsuki, N., Ikegaya, Y. GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. Nat. Med., 18:1271-1278, 2012.
Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., Ikegaya, Y. Locally synchronized synaptic inputs. Science, 335:353-356, 2012.
Sasaki, T., Matsuki, N. Ikegaya, Y. Action-potential modulation during axonal conduction. Science, 311:599-601, 2011.