Hiragi, T., Andoh, M., Araki, T., Shirakawa, T., Ono, T., Koyama, R., Ikegaya, Y. Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures. Front. Cell. Neurosci., in press.

Minamisawa, G., Funayama, K., Matsumoto, N., Matsuki, N., Ikegaya, Y. Flashing lights induce prolonged distortions in visual cortical responses and visual perception. eNeuro, in press.

Noguchi, A., Matsumoto, N., Morikawa, S. Tamura, H., Ikegaya, Y. Juvenile hippocampal CA2 region expresses aggrecan. Front. Neuroanat., in press.

Watanabe, Y., Ikegaya, Y. Caffeine increases hippocampal sharp waves in vitro. Biol. Pharm. Bull., in press.

Ouchi, A., Matsumoto, N., Ikegaya, Y. Activation of hilar mossy cells and dentate granule cells during sharp wave/ripples. Curr. Res. Neurosci., in press.

Sasaki, T., Nishimura, Y., Ikegaya, Y. Simultaneous recordings of central and peripheral bioelectrical signals in a freely moving rodent. Biol. Pharmaceut. Bull., in press.

Ihara, N., Ikegaya, Y., Takeuchi, H. Quadruple immunostaining of the olfactory bulb for visualizing the molecular identity codes of olfactory sensory axons. J. Vis. Exp., in press.

Aoki, Y., Nishimura, Y., Hondrich, T., Nakayama, R., Igata, H., Sasaki, T., Ikegaya, Y. Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model. J. Physiol. Sci., in press.

Ujita, S., Sasaki, T., Asada, A., Funayama, K., Gao, M., Mikoshiba, K., Matsuki, N., Ikegaya, Y. cAMP-dependent calcium oscillations of astrocytes: an implication for pathology. Cereb. Cortex, in press.

Dunfu, E., Ihara, N., Ligao, B., Ikegaya, Y., Takeuchi, H. Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons. Neural Dev., 12:2, 2017.

Morikawa, S., Ikegaya, Y., Narita, M., Tamura, H. Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval. Sci. Rep., 7:46024, 2017.

Gao, M., Igata, H., Takeuchi, A., Sato, K., Ikegaya, Y. Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds. J. Pharmacol. Sci., 133:70-78, 2017.

岡田桜、青木勇樹、佐々木拓哉、池谷裕二、海馬研究の最前線、Brain and Nerve、69:453-460, 2017.

佐村俊和、池谷裕二、佐藤能臣、海馬CA3培養スライスの自発的な神経発火を再現する神経回路の推定、生物物理、57:33-35, 2017.

池谷裕二、脳回路活動の構造解析、ブレインサイエンス・レビュー、43-58, 2017.


Matsumoto, N. Okamoto, K., Takagi, Y., Ikegaya, Y. 3-Hz subthreshold oscillations of CA2 neurons in vivo. Hippocampus, 26:1570-1578, 2016.

Funayama, K., Hagura, N., Ban, H., Ikegaya, Y. Functional organization of flash-induced V1 offline reactivation. J. Neurosci., 36:11727-11738, 2016.

Luo, C., Ikegaya, Y., Koyama, R. Microglia and neurogenesis in the epileptic dentate gyrus. Neurogenesis, 3:e1235525, 2016.

Mikami, Y., Kanemaru, K., Okubo, Y., Nakaune, T., Suzuki, J., Shibata, K., Sugiyama, H., Koyama, R., Murayama, T., Ito, A., Yamazawa, T., Ikegaya, Y., Sakurai, T., Saito, N., Kakizawa, S., Iino, M. Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death. EBioMedicine, 11:253-261, 2016.

Okada, S., Igata, H., Sakaguchi, T., Sasaki, T., Ikegaya, Y. A new device for the simultaneous recording of cerebral, cardiac, and muscular electrical activity in freely moving rodents. J. Pharmacol. Sci., 32:105-108, 2016.

Kasahara, Y., Koyama, R., Ikegaya, Y. Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Neurosci. Res., 111:64-69, 2016.

Makino, K., Funayama, K., Ikegaya, Y. Re-analysis on geometric energy. Anat. Sci. Int., 91:425-426, 2016.

Ando, M., Koyama, R ., Ikegaya, Y. Severity of kainic acid-induced seizures is not aggravated in the maternal immune activation mouse model of gestational poly(I:C) exposure. J. Autism Epilepsy, 1:1003, 2016.

Hirabayashi, K., Hanaoka, K., Egawa, T., Kobayashi, C., Takahashi, S., Komatsu, T., Ueno, T., Terai, T., Ikegaya, Y., Nagano, T., Urano, Y. Development of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability. Cell Calcium, 17:27, 2016.

Luo, C. Koyama, R. Ikegaya, Y. Microglia engulf viable newborn cells in the epileptic dentate gyrus. Glia, 64:1508-1517, 2016.

Ihara, N., Nakashima, A., Hoshina, N., Ikegaya, Y. Takeuchi, H. Differential expression of axon-sorting molecules in mouse olfactory sensory neurons. Eur. J. Neurosci., 44:1998-2003, 2016.

Takeda, A., Nomura, H., Masamitsu, N., Matsuki, N., Ikegaya, Y., Terai, T., Ueno, T., Hanaoka, K., Nagano, T., Urano, Y., Komatsu, T. Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA. Chembiochem, 17:1233-1240, 2016.

Nishimura, R., Abe, R., Sasaki, T., Ikegaya, Y. Homeostatic changes in neuronal network oscillations in response to continuous hypoperfusion in the mouse forebrain. Neurosci. Res., 109:28-34, 2016.

Okada, M. Ishikawa, T. Ikegaya, Y. A computationally efficient filter for reducing shot noise in low S/N data. PLOS One, 11:e0157595, 2016.

Oba, S., Nakae, K., Ikegaya, Y., Aki, S., Yoshimoto, J., Ishii, S. Empirical Bayesian significance measure of neuronal spike response. BMC Neurosci., 17:27, 2016.

Ohki, M., Sugiyama, K., Kawai, F., Tanaka, H., Nihei, Y., Unzai, S., Takebe, M., Matsunaga, S., Adachie, S., Shibayama, N., Zhou, Z., Koyama, R., Ikegaya, Y., Takahashi, T., Tame, J.R.H., Iseki, M., Park, S.Y. Structural basis for photoactivation of a light-regulated adenylate cyclase from the photosynthetic cyanobacterium Oscillatoria acuminatea. Proc. Natl. Acad. Sci. U. S. A., 113:6659-6664, 2016.

Nakayama, R., Sasaki, T., Tanaka, K. F., Ikegaya, Y. Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes. Eur. J. Neurosci., 43:923-932, 2016.

Igata, H., Sasaki, T., Ikegaya, Y. Early failures benefit subsequent task performance. Sci. Rep., 6:21293, 2016.

Nakayama, D., Hashikawa-Yamasaki, Y., Ikegaya, Y., Matsuki, N., Nomura, H. Late Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories. Sci. Rep., 6:21007, 2016.

Tao, K., Ichikawa, J., Matsuki, N., Ikegaya, Y., Koyama, R. Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. Neuroscience, 318:34-44, 2016.

Takahashi, N., Kobayashi, C., Ishikawa, T., Ikegaya, Y. Subcellular imbalances in synaptic activity. Cell Rep., 14:1348-1354, 2016.

Sajo, M., Sugiyama, H., Yamamoto, H., Tanii, T., Matsuki , N., Ikegaya, Y., Koyama, R. Neuraminidase-dependent degradation of polysialic acid is required for the lamination of newly generated neurons. PLOS One, 11:e0146398, 2016.

Zhou, Z., Tanaka, K. F., Matsunaga, S., Iseki, M., Watanabe, M., Matsuki , N., Ikegaya, Y., Koyama, R. Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Sci. Rep., 5:19679, 2016.

Makino, K., Funayama, K., Ikegaya, Y. Spatial clusters of constitutively active neurons in mouse visual cortex. Anat. Sci. Int., 91:188–195, 2016.

Koyama, R. Dentate circuitry as a model to study epileptogenesis. Biol. Pharm. Bull. 39:891-896, 2016.

安藤めぐみ、池谷裕二、小山隆太、自閉スペクトラム症とてんかん、日本薬理学雑誌、148:121-122, 2016.


Szymanska, A. F., Kobayashi, C., Norimoto, H., Ishikawa, T., Ikegaya, Y., Nenadic, Z. Accurate detection of low signal-to-noise ratio neuronal calcium transient waves using a matched filter. J. Neurosci. Meth., 259:1–12, 2015.

Hitora-Imamura, N., Miura, Y., Teshirogi, C., Ikegaya, Y., Matsuki, N., Nomura, H. Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits. eLife, 4:e08274, 2015.

Nomura, H., Hara, K., Abe, R., Hitora-Imamura, N., Nakayama, R., Sasaki, T., Matsuki, N., Ikegaya, Y. Memory formation and retrieval of neuronal silencing in the auditory cortex. Proc. Natl. Acad. Sci. U. S. A., 112:9740-9744, 2015.

Funayama, K., Minamisawa, G., Matsumoto, N., Ban, H., Chan, A. W., Matsuki, N., Murphy, T. H., Ikegaya, Y. Neocortical rebound depolarization enhances visual perception. PLOS Biol., 13:e1002231, 2015.

Asada, A., Ujita, S., Nakayama, R., Oba, S., Ishii, S., Matsuki, N., Ikegaya, Y. Subtle modulation of ongoing calcium dynamics in astrocytic microdomains by sensory inputs. Physiol. Rep., 3:e12454, 2015.

Hongo, Y., Ogawa, K., Takahara, Y., Takasu, K., Royer, S., Hasegawa, M., Sakaguchi, G., Ikegaya, Y. Topological organization of CA3-to-CA1 excitation. Eur. J. Neurosci., 42:2135-2143, 2015.

Hongo, Y., Takasu, K., Ikegaya, Y., Hasegawa, M., Sakaguchi, G., Ogawa, K. Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model: a functional multineuron calcium imaging study. Eur. J. Neurosci., 42:1818-1829, 2015.

Kitanishi, T., Ujita, S., Fallahnezhad, M., Kitanishi, N., Ikegaya, Y., Tashiro, A. Novelty-induced phase-locked firing to slow gamma oscillations in the hippocampus: requirement of synaptic plasticity. Neuron, 86:1265-1276, 2015.

Ishikawa, T., Okamoto, K., Ikegaya, Y. Homeostatic hippocampal activity against reduced glutamatergic neurotransmission. Int. J. Pharmacol., 11:318-326, 2015.

Shimazaki, H., Sadegh, K., Ishikawa, T., Ikegaya, Y., Toyoizum, T. Simultaneous silence organizes structured higher-order interactions in neural populations. Sci. Rep., 5:9821, 2015.

Norimoto, H., Ikegaya, Y. Visual cortical prosthesis with a geomagnetic compass restores spatial navigation in blind rats. Curr. Biol., 21:1091–1095, 2015.

Iwasaki, S., Sakaguchi, T., Ikegaya, Y. Brief fear preexposure facilitates subsequent fear conditioning. Neurosci. Res., 95:66–73, 2015.

Nakayama, D., Iwata, H., Teshirogi, C., Ikegaya, Y., Matsuki, N., Nomura, H. Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. J. Neurosci., 5:819–830, 2015.

Nakayama, D., Baraki, Z., Onoue, K., Ikegaya, Y., Matsuki, N., Nomura, H. Frontal association cortex is engaged in stimulus integration during associative learning. Curr. Bol., 25:117-123, 2015.

Koyama, R., Ikegaya Y., Microglia in the pathogenesis of autism spectrum disorders. Neurosci. Res., 100:1-5, 2015.

Samura, T., Ikegaya, Y., Sato, Y. D. A neural network model of reliably optimized spike transmission. Cogn. Neurodyn., 9:265-77, 2015.

西村侑也、杉山弘樹、池谷裕二、Q&A-神経科学の素朴な疑問、Clin. Neurosci.、 33:1434, 2015.

小島弘人、坂口哲也、池谷裕二、記憶の脳回路痕跡、Brain and Nerve、67:599-604, 2015.

高木夕貴、杉山弘樹、池谷裕二、海馬における記憶再生のメカニズム、Clin. Neurosci.、33:225-225, 2015.


Nakae, K., Ikegaya, Y., Ishikawa, T., Oba, S., Urakubo, H., Koyama, M., Ishii, S. A statistical method of identifying interactions in neuron–glia systems based on functional multicell calcium imaging. PLOS Comput. Biol., 10:e1003949, 2014.

Abe, R., Sakaguchi, T., Kitajo, K., Ishikawa, D., Matsumoto, N., Matsuki, N., Ikegaya, Y. Sound-induced modulation of hippocampal theta oscillations. Neuroreport, 25:1368-1374, 2014.

Okamoto, K., Ishikawa, T., Abe, R., Ishikawa, D., Kobayashi, C., Mizunuma, M., Norimoto, H., Matsuki, N., Ikegaya, Y. Ex vivo cultured neuronal networks emit in vivo-like spontaneous activity. J. Physiol. Sci., 64:421-431, 2014.

Miyawaki, T., Norimoto, H., Ishikawa, T., Watanabe, Y., Matsuki, N., Ikegaya, Y. Dopamine receptor activation reorganizes neuronal ensembles during hippocampal sharp waves in vitro. PLOS One, 9:e104438, 2014.

Nonaka, A., Toyoda, T., Miura, Y., Hitora-Imamura, N., Naka, M., Eguchi, M., Yamaguchi, S., Ikegaya, Y., Matsuki, N., Nomura, H. Synaptic plasticity associated with a memory engram in the basolateral amygdala. J. Neurosci., 34:9305–9309, 2014.

Tao, K., Matsuki, N., Koyama, R., AMP-activated protein kinase mediates activity-dependent axon branching by recruiting mitochondria to axon. Dev. Neurobiol., 74:557-573, 2014.

Abe, R., Sakaguchi, T., Matsumoto, N., Matsuki, N., Ikegaya, Y. Sound-induced hyperpolarization of hippocampal neurons. Neuroreport, 25:1013-1017, 2014.

Onoue, K., Nakayama, D., Ikegaya, Y., Matsuki, N., Nomura, H. Fear extinction requires Arc/Arg3.1 expression in the basolateral amygdala. Mol. Brain, 7:30, 2014.

Sasaki, T., Ishikawa, T., Abe, R., Nakayama, R., Asada, A., Matsuki, N., Ikegaya, Y. Astrocyte calcium signaling orchestrates neuronal synchronization in organotypic hippocampal slices. J. Physiol., 592:2771-2783, 2014.

Sasaki, T., Matsuki, N., Ikegaya, Y. Interneuron firing precedes sequential activation of neuronal ensembles in hippocampal slices. Eur. J. Neurosci., 39:2027-2036, 2014.

Ishikawa, D., Matsumoto, N., Sakaguchi, T., Matsuki, N., Ikegaya, Y. Operant conditioning of synaptic and spiking activity patterns in single hippocampal neurons. J. Neurosci., 34:5044-5053, 2014.

Mizunuma, M., Norimoto, H., Tao, K., Egawa, T., Hanaoka, K., Sakaguchi, T., Hioki, H., Kaneko, T., Yamaguchi, S., Nagano, T., Matsuki, N., Ikegaya, Y. Unbalanced excitability underlies offline reactivation of behaviorally activated neurons. Nat. Neurosci., 17:503-505, 2014.

Kobayashi, C., Ohkura, M., Nakai, J., Matsuki, N., Ikegaya, Y., Sasaki, T. Large-scale imaging of subcellular calcium dynamics of cortical neurons with G-CaMP6-actin. Neuroreport, 25:501-506, 2014.

Before 2013 (selected)

Koyama, R., Tao, K., Sasaki, T., Ichikawa, J., Miyamoto, D., Muramatsu, R., Matsuki, N., Ikegaya, Y. GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. Nat. Med., 18:1271-1278, 2012.

Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., Ikegaya, Y. Locally synchronized synaptic inputs. Science, 335:353-356, 2012.

Sasaki, T., Matsuki, N. Ikegaya, Y. Action-potential modulation during axonal conduction. Science, 311:599-601, 2011.